AnthWest is a large dataset, one of the outcomes of a comprehensive, broadly comparative study on the diversity, biology, biogeography, and evolution of Anthidium Fabricius in the Western Hemisphere. In this dataset a total of 22,648 adult occurrence records comprising 9,657 unique events are documented for 92 species of Anthidium, including the invasive range of two introduced species from Eurasia, A. oblongatum (Illiger) and A. manicatum (Linnaeus). The geospatial coverage of the dataset extends from northern Canada and Alaska to southern Argentina, and from below sea level in Death Valley, California, USA, to 4,700 m a.s.l. in Tucumán, Argentina. The majority of the records in the dataset correspond to information recorded from individual specimens examined by the authors during this project, and deposited into 60 biodiversity collections located in Africa, Europe, North and South America.