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Data from: Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans

An investigation of antigenic relationships between North American swine H3N2 influenza A viruses (IAV) and human seasonal vaccine strains was conducted to assess the zoonotic risk to humans. Human seasonal H3N2 vaccine strains isolated from 1973 to 2014 (n=20) were obtained from the World Health Organization Global Influenza Surveillance and Response Network through St. Jude Children’s Research Hospital to use for serological assays, such as hemagglutination inhibition (HI) assays. Human seasonal vaccine strains were cultured on MDCK cells or eggs and the HA gene was verified by sequencing on a Sanger method at National Animal Disease Center (NADC). A consensus HA sequence was generated using Geneious Software.

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FieldValue
Tags
H3N2
human vaccine
antigenic cartography
influenza
NP103
Modified
2021-11-16
Release Date
2021-05-03
Identifier
236eaee3-ac9c-4fb6-89f8-cc3be5a26007
Spatial / Geographical Coverage Area
POLYGON ((-165.76171875 25.572175556682, -165.76171875 71.995974056837, -51.85546875 71.995974056837, -51.85546875 25.572175556682))
Publisher
Ag Data Commons
Spatial / Geographical Coverage Location
North America
Temporal Coverage
January 1, 1973 to December 31, 2014
License
U.S. Public Domain
Contact Name
Vincent, Amy L.
Contact Email
amy.vincent@usda.gov
Public Access Level
Public
Program Code
005:040 - Department of Agriculture - National Research
Bureau Code
005:18 - Agricultural Research Service
Extended Metadata: 
FieldValue
Authors
Souza, Carine K. (ORCID)
Anderson, Tavis K. (ORCID)
Chang, Jennifer (ORCID)
Venkatesh, Divya (ORCID)
Lewis, Nicola S. (Scopus Author ID)
Pekosz, Andrew (ORCID)
Shaw-Saliba, Kathryn (Scopus Author ID)
Rothman, Richard E. (ORCID)
Chen, Kuan-Fu (ORCID)
Vincent, Amy L. (ORCID)
Peer Reviewed
No
Intended Use
This data may be used to confirm human H3N2 vaccine strains sequences to study antigenic drift from swine H3N2 influenza A virus.
Funding Sources
Agricultural Research Service
0500-00093-001-00-D
National Institute of Allergy and Infectious Diseases
HHSN272201400008C
National Institute of Allergy and Infectious Diseases
HHSN272201400007C
Oak Ridge Institute for Science and Education
DE-AC05-06OR23100
Primary Article

Souza, C. K., Anderson, T. K., Chang, J., Venkatesh, D., Lewis, N. S., Pekosz, A., Shaw-Saliba, K., Rothman, R. E., Chen, K.-F., & Vincent, A. L. (2021). Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans. Journal of Virology. https://doi.org/10.1128/jvi.01374-21
Dataset DOI (digital object identifier)
10.15482/USDA.ADC/1522389
Product Type
Dataset
FieldValue
OSTI Identifier
ISO Topic(s)
biota
health
National Agricultural Library Thesaurus Term
swine
humans
Influenza A virus
risk
vaccines
World Health Organization
influenza
monitoring
children
hospitals
immunologic techniques
hemagglutination
eggs
genes
animal diseases
computer software
zoonoses
antigenic variation
Ag Data Commons Keywords
  • Animals & Livestock
  • Animal health
  • Animals & Livestock
  • Genomics & Genetics

Suggested Citations:

(original article) Souza, C. K., Anderson, T. K., Chang, J., Venkatesh, D., Lewis, N. S., Pekosz, A., Shaw-Saliba, K., Rothman, R. E., Chen, K.-F., & Vincent, A. L. (2021). Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans. Journal of Virology. https://doi.org/10.1128/jvi.01374-21

(dataset) Souza, Carine K.; Anderson, Tavis K.; Chang, Jennifer; Venkatesh, Divya; Lewis, Nicola S.; Pekosz, Andrew; Shaw-Saliba, Kathryn; Rothman, Richard E.; Chen, Kuan-Fu; Vincent, Amy L. (2021). Data from: Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans. Ag Data Commons. https://doi.org/10.15482/USDA.ADC/1522389. Accessed 2023-09-28.