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Data from: The data of change in macrophage gene expression which [is] induced by perilipin 1 overexpression

The data presented are related to the research article entitled "Overexpression of Perilipin1 protects against atheroma progression in apolipoprotein E knockout mice". This Data in Brief paper describes data that were obtained from perilipin 1 (PLIN1) transgenic mice (Plin1Tg) regarding atherosclerosis. The main aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis. The data were collected from C57BL/6J mice, apolipoprotein E knockout mice (ApoeKO) and Plin1Tg/ApoeKO. The atherosclerotic lesion areas of aorta were 3.3 ± 1.2% in C57BL/6J mice, 14.2 ± 3.2% in ApoeKO, and 5.6 ± 1.9% in Plin1Tg/ApoeKO. Body weight, gonadal adipose mass and plasma triglyceride concentrations were comparable among the three groups [1]. Furthermore, PLIN1 overexpression did not affect the gene expressions related to cholesterol influx and efflux in macrophage.

Overexpression of PLIN1 in macrophages protected against atheroma progression. No major risk factors were altered in PLIN1 transgenic mice fed normal diet. Overexpression of PLIN1 did not affect the gene expressions related to cholesterol influx and efflux in macrophage.

FieldValue
Tags
Modified
2019-08-05
Release Date
2018-05-21
Identifier
4e3ac55b-76e1-4e14-9355-4afc6aade42c
Publisher
Data in Brief
License
Contact Name
Miyoshi, Hideaki
Contact Email
Public Access Level
Public
Program Code
005:040 - Department of Agriculture - National Research
Bureau Code
005:18 - Agricultural Research Service