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Data from: The data of change in macrophage gene expression which [is] induced by perilipin 1 overexpression

The data presented are related to the research article entitled "Overexpression of Perilipin1 protects against atheroma progression in apolipoprotein E knockout mice". This Data in Brief paper describes data that were obtained from perilipin 1 (PLIN1) transgenic mice (Plin1Tg) regarding atherosclerosis. The main aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis. The data were collected from C57BL/6J mice, apolipoprotein E knockout mice (ApoeKO) and Plin1Tg/ApoeKO. The atherosclerotic lesion areas of aorta were 3.3 ± 1.2% in C57BL/6J mice, 14.2 ± 3.2% in ApoeKO, and 5.6 ± 1.9% in Plin1Tg/ApoeKO. Body weight, gonadal adipose mass and plasma triglyceride concentrations were comparable among the three groups [1]. Furthermore, PLIN1 overexpression did not affect the gene expressions related to cholesterol influx and efflux in macrophage.

Overexpression of PLIN1 in macrophages protected against atheroma progression. No major risk factors were altered in PLIN1 transgenic mice fed normal diet. Overexpression of PLIN1 did not affect the gene expressions related to cholesterol influx and efflux in macrophage.

Dataset Info

These fields are compatible with DCAT, an RDF vocabulary designed to facilitate interoperability between data catalogs published on the Web.
FieldValue
Authors
Yamamoto, Kohei
Miyoshi, Hideaki
Cho, Kyu Yong
Nakamura, Akinobu
Greenberg, Andrew S.
Atsumi, Tatsuya
Intended Use
The aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis.
Publisher
Data in Brief
Contact Name
Miyoshi, Hideaki
Contact Email
hmiyoshi@med.hokudai.ac.jp
Public Access Level
Public
Primary Article

Yamamoto, Kohei, Miyoshi, Hideaki, Cho, Kyu Yong, Nakamura, Akinobu, Greenberg, Andrew S. , Atsumi, Tatsuya (2018) The data of change in macrophage gene expression which induced by perilipin 1 overexpression, Data in Brief, Available online 15 May 2018, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2018.05.027.

Related Article

Yamamoto, K., Miyoshi, H., Cho, K. Y., Nakamura, A., Greenberg, A. S., & Atsumi, T. (2018). Overexpression of perilipin1 protects against atheroma progression in apolipoprotein E knockout mice, Atherosclerosis, 269:192-196

DOI: 10.1016/j.atherosclerosis.2018.01.019
License
Creative Commons Attribution
Funding Source(s)
Agricultural Research Service
Dataset DOI (digital object identifier)
10.1016/j.dib.2018.05.027
Program Code
005:037 - Department of Agriculture - Research and Education
Bureau Code
005:18 - Agricultural Research Service
Modified Date
2018-12-04
Release Date
2018-05-21
Ag Data Commons Keywords: 
  • Food & Nutrition
  • Food composition
  • Genomics & Genetics
  • Expression analysis
National Agricultural Library Thesaurus Term: 
apolipoprotein E
knockout mutants
transgenic animals
genetically modified organisms
mice
atherosclerosis
pathophysiology
aorta
body weight
gonads
triacylglycerols
gene expression
gene overexpression
cholesterol
macrophages
User-supplied Tags: 
perilipin-1
PLIN1
ISO Topic(s): 
biota

Suggested Citations:

(original article) Yamamoto, Kohei, Miyoshi, Hideaki, Cho, Kyu Yong, Nakamura, Akinobu, Greenberg, Andrew S. , Atsumi, Tatsuya (2018) The data of change in macrophage gene expression which induced by perilipin 1 overexpression, Data in Brief, Available online 15 May 2018, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2018.05.027.

(dataset) Yamamoto, Kohei; Miyoshi, Hideaki; Cho, Kyu Yong; Nakamura, Akinobu; Greenberg, Andrew S.; Atsumi, Tatsuya (2018). Data from: The data of change in macrophage gene expression which [is] induced by perilipin 1 overexpression. Data in Brief. http://dx.doi.org/10.1016/j.dib.2018.05.027