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Data from: The data of change in macrophage gene expression which [is] induced by perilipin 1 overexpression

The data presented are related to the research article entitled "Overexpression of Perilipin1 protects against atheroma progression in apolipoprotein E knockout mice". This Data in Brief paper describes data that were obtained from perilipin 1 (PLIN1) transgenic mice (Plin1Tg) regarding atherosclerosis. The main aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis. The data were collected from C57BL/6J mice, apolipoprotein E knockout mice (ApoeKO) and Plin1Tg/ApoeKO. The atherosclerotic lesion areas of aorta were 3.3 ± 1.2% in C57BL/6J mice, 14.2 ± 3.2% in ApoeKO, and 5.6 ± 1.9% in Plin1Tg/ApoeKO. Body weight, gonadal adipose mass and plasma triglyceride concentrations were comparable among the three groups [1]. Furthermore, PLIN1 overexpression did not affect the gene expressions related to cholesterol influx and efflux in macrophage.

Overexpression of PLIN1 in macrophages protected against atheroma progression. No major risk factors were altered in PLIN1 transgenic mice fed normal diet. Overexpression of PLIN1 did not affect the gene expressions related to cholesterol influx and efflux in macrophage.

Dataset Info

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FieldValue
Authors
Yamamoto, Kohei
Miyoshi, Hideaki
Cho, Kyu Yong
Nakamura, Akinobu
Greenberg, Andrew S.
Atsumi, Tatsuya
Intended Use
The aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis.
Publisher
Data in Brief
Contact Name
Miyoshi, Hideaki
Contact Email
Public Access Level
Public
Primary Article

Yamamoto, Kohei, Miyoshi, Hideaki, Cho, Kyu Yong, Nakamura, Akinobu, Greenberg, Andrew S. , Atsumi, Tatsuya (2018) The data of change in macrophage gene expression which induced by perilipin 1 overexpression, Data in Brief, Available online 15 May 2018, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2018.05.027.

Related Article

Yamamoto, K., Miyoshi, H., Cho, K. Y., Nakamura, A., Greenberg, A. S., & Atsumi, T. (2018). Overexpression of perilipin1 protects against atheroma progression in apolipoprotein E knockout mice, Atherosclerosis, 269:192-196

License
Funding Source(s)
Agricultural Research Service
Dataset DOI (digital object identifier)
10.1016/j.dib.2018.05.027
Program Code
005:037 - Department of Agriculture - Research and Education
Bureau Code
005:18 - Agricultural Research Service
Modified Date
2018-12-04
Release Date
2018-05-21
Ag Data Commons Keywords: 
  • Food & Nutrition
  • Food composition
  • Genomics & Genetics
  • Expression analysis
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