The data presented are related to the research article entitled "Overexpression of Perilipin1 protects against atheroma progression in apolipoprotein E knockout mice". This Data in Brief paper describes data that were obtained from perilipin 1 (PLIN1) transgenic mice (Plin1Tg) regarding atherosclerosis. The main aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis. The data were collected from C57BL/6J mice, apolipoprotein E knockout mice (ApoeKO) and Plin1Tg/ApoeKO. The atherosclerotic lesion areas of aorta were 3.3 ± 1.2% in C57BL/6J mice, 14.2 ± 3.2% in ApoeKO, and 5.6 ± 1.9% in Plin1Tg/ApoeKO. Body weight, gonadal adipose mass and plasma triglyceride concentrations were comparable among the three groups . Furthermore, PLIN1 overexpression did not affect the gene expressions related to cholesterol influx and efflux in macrophage.
Overexpression of PLIN1 in macrophages protected against atheroma progression. No major risk factors were altered in PLIN1 transgenic mice fed normal diet. Overexpression of PLIN1 did not affect the gene expressions related to cholesterol influx and efflux in macrophage.
- The data of change in macrophage gene expression which [is] induced by perilipin 1 overexpressionhtml
Thioglycollate-elicited peritoneal macrophages were isolated from C57BL/6J...
Dataset InfoThese fields are compatible with DCAT, an RDF vocabulary designed to facilitate interoperability between data catalogs published on the Web.
The aim of collecting the data was to clarify the role of PLIN1 in the pathophysiology of atherosclerosis.
Data in Brief
|Public Access Level|
Yamamoto, Kohei, Miyoshi, Hideaki, Cho, Kyu Yong, Nakamura, Akinobu, Greenberg, Andrew S. , Atsumi, Tatsuya (2018) The data of change in macrophage gene expression which induced by perilipin 1 overexpression, Data in Brief, Available online 15 May 2018, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2018.05.027.
Yamamoto, K., Miyoshi, H., Cho, K. Y., Nakamura, A., Greenberg, A. S., & Atsumi, T. (2018). Overexpression of perilipin1 protects against atheroma progression in apolipoprotein E knockout mice, Atherosclerosis, 269:192-196
Agricultural Research Service
|Dataset DOI (digital object identifier)|
005:037 - Department of Agriculture - Research and Education
005:18 - Agricultural Research Service
- Food & Nutrition
- Food composition
- Genomics & Genetics
- Expression analysis