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Data from: Genome Sequence of the Thermotolerant Foodborne Pathogen Salmonella enterica Serovar Senftenberg ATCC 43845 and Phylogenetic Analysis of Loci Encoding Increased Protein Quality Control Mechanisms

Salmonella enterica subsp. enterica bacteria are important foodborne pathogens with major economic impact. Some isolates exhibit increased heat tolerance, a concern for food safety. Analysis of a finished-quality genome sequence of an isolate commonly used in heat resistance studies, S. enterica subsp. enterica serovar Senftenberg 775W (ATCC 43845), demonstrated an interesting observation that this strain contains not just one, but two horizontally acquired thermotolerance locus homologs. These two loci reside on a large 341.3-kbp plasmid that is similar to the well-studied IncHI2 R478 plasmid but lacks any antibiotic resistance genes found on R478 or other IncHI2 plasmids. As this historical Salmonella isolate has been in use since 1941, comparative analysis of the plasmid and of the thermotolerance loci contained on the plasmid will provide insight into the evolution of heat resistance loci as well as acquisition of resistance determinants in IncHI2 plasmids.

Dataset Info

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FieldValue
Authors
Nguyen, Scott V.
(ORCID)
Harhay, Gregory P.
(ORCID)
Bono, James L.
(ORCID)
Smith, Timothy P.L.
(ORCID)
Harhay, Dayna M.
(ORCID)
Product Type
Genome/Genetics Data
Intended Use
Complete sequence analysis of a historical isolate of Salmonella enterica serovar Senftenberg, used in numerous studies because of its novel heat resistance, revealed that this important strain possesses two distinct copies of this conserved thermotolerance locus, residing on a multireplicon IncHI2/IncHI2A plasmid. Phylogenetic analysis of these loci in comparison with homologs identified in various bacterial genera provides an opportunity to examine the evolution and distribution of loci conferring resistance to environmental stressors, such as heat and desiccation.
Publisher
mSystems
Contact Name
Harhay, Dayna M.
Contact Email
Public Access Level
Public
Preferred Dataset Citation
Nguyen, S. V., Harhay, G. P., Bono, J. L., Smith, T. P. L., & Harhay, D. M. (2017). Genome Sequence of the Thermotolerant Foodborne Pathogen Salmonella enterica Serovar Senftenberg ATCC 43845 and Phylogenetic Analysis of Loci Encoding Increased Protein Quality Control Mechanisms. <em>mSystems</em> 2(1), e00190-16. https://doi.org/10.1128/mSystems.00190-16
Primary Article

Nguyen, S. V., Harhay, G. P., Bono, J. L., Smith, T. P. L., & Harhay, D. M. (2017). Genome Sequence of the Thermotolerant Foodborne Pathogen Salmonella enterica Serovar Senftenberg ATCC 43845 and Phylogenetic Analysis of Loci Encoding Increased Protein Quality Control Mechanisms. mSystems 2(1), e00190-16.

License
Funding Source(s)
Agricultural Research Service
Dataset DOI (digital object identifier)
10.1128/mSystems.00190-16
Program Code
005:037 - Department of Agriculture - Research and Education
Bureau Code
005:18 - Agricultural Research Service
Modified Date
2018-12-06
Release Date
2018-09-20
Ag Data Commons Keywords: 
  • Genomics & Genetics
  • Genome
  • Genomics & Genetics
  • Sequence Assembly
  • Food & Nutrition
  • Food safety
  • Food & Nutrition
  • Genomics & Genetics
ISO Topic(s):