File contains transcriptomics results for gastrocnemius (GA) and soleus (SOL) muscles from adult mice, previously fed a 45% (by energy) high fat diet for ~13 wk. The Supplemental Material also contains gene pathway analysis results (e.g., GO, HMDB), transcripts differentially expressed but with shared or disparate patterns in GA vs. SOL (Venn diagrams), and correlations between summed muscle weights vs. body weight or lean body mass.