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Data from: Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum

RNA expression analysis was performed on the corpus luteum tissue at five time points after prostaglandin F2 alpha treatment of midcycle cows using an Affymetrix Bovine Gene v1 Array. The normalized linear microarray data was uploaded to the NCBI GEO repository (GSE94069). Subsequent statistical analysis determined differentially expressed transcripts ± 1.5-fold change from saline control with P ≤ 0.05. Gene ontology of differentially expressed transcripts was annotated by DAVID and Panther. Physiological characteristics of the study animals are presented in a figure. Bioinformatic analysis by Ingenuity Pathway Analysis was curated, compiled, and presented in tables. A dataset comparison with similar microarray analyses was performed and bioinformatics analysis by Ingenuity Pathway Analysis, DAVID, Panther, and String of differentially expressed genes from each dataset as well as the differentially expressed genes common to all three datasets were curated, compiled, and presented in tables. Finally, a table comparing four bioinformatics tools' predictions of functions associated with genes common to all three datasets is presented. These data have been further analyzed and interpreted in the companion article "Early transcriptome responses of the bovine mid-cycle corpus luteum to prostaglandin F2 alpha includes cytokine signaling".

Dataset Info

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FieldValue
Authors
Talbott, Heather
(ORCID)
Hou, Xiaoying
Qiu, Fang
Zhang, Pan
Guda, Chittibabu
(ORCID)
Yu, Fang
Cushman, Robert A.
(ORCID)
Wood, Jennifer R.
Wang, Cheng
Cupp, Andrea S.
Davis, John S.
Product Type
Dataset
Equipment or Software Used
Intended Use
Study of bovine mid-cycle corpus luteum response to prostaglandin F2 alpha with respect to cytokine activation as a target for improving fertility.
Publisher
Data in Brief
Contact Name
Davis, John S.
Contact Email
Public Access Level
Public
Primary Article

Talbott, H., Hou, X., Qiu, F., Zhang, P., Guda, C., Yu, F., Cushman, R. A., Wood, J. R., Wang, C., Cupp, A. S., & Davis, J. S., (2017). Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum, Data in Brief, 14:695-706

Related Article

Myer, P. R., Kim, M. S., Freetly, H. C., Smith, T. P. L., (2016). Evaluation of 16S rRNA amplicon sequencing using two next-generation sequencing technologies for phylogenetic analysis of the rumen bacterial community in steers. Journal of Microbiological Methods 127:132-140

Talbott, H., Hou, X., Qiu, F., Zhang, P. et al. (2017). Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling. Mol. Cell. Endocrinol., 452:93-109. PMID: 28549990

License
Funding Source(s)
National Institute of Food and Agriculture
2014–67011-22280
National Institute of Food and Agriculture
2011–67015-20076
National Institute of Food and Agriculture
2013–67015-20965
U.S. Department of Agriculture
Hatch grant NEB26-202/W2112
U.S. Department of Agriculture
Hatch grant eNEB ANHL 26–213
U.S. Department of Agriculture
Hatch grant NEB 26–206
Agricultural Research Service
Project Plan 3040–31000-093-00D
NBRE - P20GM103427-14
COBRE - 1P30GM110768-01
Program Code
005:037 - Department of Agriculture - Research and Education
Bureau Code
005:18 - Agricultural Research Service
Modified Date
2018-12-06
Release Date
2017-12-12
Ag Data Commons Keywords: 
  • Genomics & Genetics
  • Transcriptome
  • Genomics & Genetics
  • Animals & Livestock
  • Genomics & Genetics
  • Expression analysis
ISO Topic(s):