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Data Extent

Effect of Holstein genotype on immune response to an intramammary Escherichia coli challenge

Since 1964, the University of Minnesota has selectively bred a Holstein herd to maintain genetically static, unselected Holsteins (UH). Comparison of these UH cows with contemporary Holstein (CH) has demonstrated that the UH cows not only produce less milk but also have fewer health concerns than their CH herdmates. The objective of this study was to determine the effects of Holstein genotype on innate immune response in an experimental intramammary E. coli challenge model. Primiparous UH (n= 5) and CH (n = 7) cows received 430 cfu E. coli strain P4 in 1 quarter. Blood samples were collected at 0, 0.5, 1, 2, 7d relative to E. coli infusion. RNA Sequencing was conducted using the HiSeq 2500 platform (Illumina, San Diego, CA) to generate an average of 46.96 ± 2.67 million 100 bp paired end reads per sample.

For more information about this dataset contact:
John Lippolis: john.lippolis@usda.gov
Hao Ma: hao.ma@usda.gov

FieldValue
Tags
Modified
2023-09-19
Release Date
2022-02-28
Frequency
Continuously
Identifier
3a059c4b-04f6-4fad-94a3-c5dd7d9932f4
Spatial / Geographical Coverage Area
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Publisher
Ag Data Commons
Spatial / Geographical Coverage Location
Iowa, Minnesota
Temporal Coverage
September 1, 2018 to September 30, 2018
License
Contact Name
Lippolis, John
Contact Email
Public Access Level
Public
Program Code
005:040 - Department of Agriculture - National Research
Bureau Code
005:18 - Agricultural Research Service