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Vaccination Against Lawsonia intracellularis Decreases Shedding of Salmonella enterica serovar Typhimurium in Co-Infected Pigs and Alters the Gut Microbiome

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Salmonella enterica is a leading cause of foodborne illness worldwide and pork can serve a source of infection. In this study, we investigated if vaccinating pigs against Lawsonia intracellularis, a common pathogen of swine that has previously been shown to favor Salmonella enterica infection, confers protection against Salmonella enterica serovar Typhimurium. We investigated the underlying changes in the gut microbiome mediated by single S. Typhiumurium infection compared to co-infection with L. intracellularis as well as the effect of vaccination on the microbiome. In this study, a total of five treatment groups were used: 1) challenged with S. Typhimurium alone (Sal), 2) challenged with both S. Typhimurium and L. intracellularis (Sal Law), 3) challenged with S. Typhimurium and vaccinated against L. intracellularis (Sal Vac), 4) challenged with both S. Typhimurium and L. intracellularis and vaccinated against L. intracellularis (Sal Law Vac), and 5) non-infected control (Control).

Deposited here are fastq files of sequencing of the V1-V3 region of the 16S rRNA gene from feces of each animal of the study from the time point of prior to infection (0 days post infection) to 49 days post infection. Descriptions of each sample are in the mapping file named “MappingFileSubmission.txt”. The sequences are in the file “FastqCoinfectionMicrobiome.tar.gz”.

Dataset Info

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FieldValue
Authors
Leite, Fernando L.L.
(ORCID)
Singer, Randall S.
(ORCID)
Ward, Tonya
(ORCID)
Gebhart, Connie J.
Isaacson, Richard
(ORCID)
Product Type
Genome/Genetics Data
Spatial / Geographical Coverage Location
St. Paul, Minnesota
Temporal Coverage
2016-02-10/2016-04-06
Equipment or Software Used
Publisher
University of Minnesota
Contact Name
Isaacson, Richard
Contact Email
Public Access Level
Public
Preferred Dataset Citation
Leite, Fernando L L; Singer, Randall S; Ward, Tonya; Gebhart, Connie J; Isaacson, Richard E. (2017). Vaccination Against Lawsonia intracellularis Decreases Shedding of Salmonella enterica serovar Typhimurium in Co-Infected Pigs and Alters the Gut Microbiome. Retrieved from the Data Repository for the University of Minnesota, https://doi.org/10.13020/D60114
Primary Article

Leite, F., Singer, R., Ward, T., Gebhart, C., & Isaacson, R. (2018). Vaccination Against Lawsonia intracellularis Decreases Shedding of Salmonella enterica serovar Typhimurium in Co-Infected Pigs and Alters the Gut Microbiome. Scientific Reports, 8(1).

License
Funding Source(s)
National Institute of Food and Agriculture
1005423
Dataset DOI (digital object identifier)
10.13020/D60114
Modified Date
2019-02-10
Release Date
2018-06-07
Ag Data Commons Keywords: 
  • Genomics & Genetics
State or Territory: 
ISO Topic(s):