This dataset consists of growth and yield data for upland cotton [*Gossypium hirsutum* (L.)] grown for lint and seed at the USDA-ARS Conservation and Production Research Laboratory (CPRL), Soil and Water Management Research Unit (SWMRU), Bushland, Texas (Lat. 35.186714°, Long. -102.094189°, elevation 1170 m above MSL) in 2000 through 2004, 2008, 2010, 2012, and 2020 on up to four large, precision weighing lysimeters, each in the center of a 4.44 ha square field similarly cropped. Crops were grown variously under irrigated, deficit irrigated, and dryland conditions. The datasets for individual season years consist of soil water content, weather, crop growth and yield, agronomic calendar, water balance (evapotranspiration, precipitation, dew/frost, irrigation), and lysimeter energy and water balance data. Water management treatments ranged from irrigation replenishing crop water use fully every week (full) to deficit irrigations ranging down to 1/3 of full, and to dryland cropping without irrigation. Irrigation application methods included sprinkler and subsurface drip irrigation. The entire datasets for individual season years consist of soil water content, weather, crop growth and yield, agronomic calendar, water balance (evapotranspiration, precipitation, dew/frost, irrigation), and lysimeter energy and water balance data. This dataset focuses on the cotton growth and yield data.