This dataset consists of growth and yield data for soybean [Glycine max (L.) Merr.] grown for seed at the USDA-ARS Conservation and Production Laboratory (CPRL), Soil and Water Management Research Unit (SWMRU), Bushland, Texas (Lat. 35.186714°, Long. -102.094189°, elevation 1170 m above MSL) in 1995, 2003, 2004, 2010 and 2019. In the 1995, 2003, 2004, and 2010 seasons, soybean was grown on two large, precision weighing lysimeters, each in the center of a 4.44 ha square field. In 2019, soybean was grown on four large, precision weighing lysimeters and their surrounding and contiguous 4.4 ha square fields. The entire datasets for individual season years consist of soil water content, weather, crop growth and yield, agronomic calendar, water balance (evapotranspiration, precipitation, dew/frost, irrigation), and lysimeter energy and water balance data. This dataset focuses on the soybean growth and yield data.