Caffeoyl-coenzyme A 3-O-methyltransferase (CCoAOMT) is an S-adenosyl methionine (SAM)-dependent O-methyltransferase responsible for methylation of the *meta*-hydroxyl group of caffeoyl-coenzyme A (CoA) on the pathway to monolignols, with their ring methoxylation status characteristic of guaiacyl or syringyl units in lignin. In order to better understand the unique class of type 2 O-methyltransferases from monocots, we have characterized CCoAOMT from sorghum (*Sorghum bicolor*; SbCCoAOMT), including the SAM binary complex crystal structure and steady-state enzyme kinetics.

Plasma metabolite patterns were determined during exercise and recovery in overnight-fasted sedentary, obese, insulin resistant women under controlled conditions of diet and physical activity to test the hypothesisis that improved fitness and insulin sensitivity following a ~14 wk training and weight loss intervention would lead to fixed workload plasma metabolomics signatures reflective of metabolic health and muscle metabolism. Supporting Materials include graphs of blood patterns of metabolites in adult women during a sub-maximal exercise bout and recovery period, and primary data in spreadsheet format on model performance, exercise and recovery, and correlation statistics for metabolites.

The primary mission of the Alliance of Genome Resources (the Alliance) is to develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, health and disease. This understanding is fundamental for advancing genome biology research and for translating human genome data into clinical utility.

The Research Projects Database (RPD) provides current food safety research projects from both U.S. and international government, and non-government organizations.